Jamming and force distribution in growing epithelial tissue
نویسندگان
چکیده
We investigate morphologies of proliferating cellular tissues using a newly developed numerical simulation model for mechanical cell division and migration in 2D. The is applied to bimodal mixture consisting stiff cells with low growth potential soft high potential; cancer are typically considered be softer than healthy cells. In an even mixture, the develop into tissue matrix dendrite-like network structure. When placed inside (to growth), fast growing tumor-like structure that gradually evacuates matrix. also demonstrates 1) how orient themselves direction largest effective stiffness as predicted by theory Bischofs Schwarz (Proc. Natl. Acad. Sci U.S.A., 100, 9274--9279 (2003) 2) orientation force generation continue few rows behind soft-stiff interface. With increasing inter-cell friction, tumor slows down death occurs. contact distribution between demonstrated highly sensitive type mixtures cell-cell interactions, which indicates local forces can useful regulator formation. results shed new light on established experimental data.
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ژورنال
عنوان ژورنال: Physical review research
سال: 2021
ISSN: ['2643-1564']
DOI: https://doi.org/10.1103/physrevresearch.3.023129